Reaction #87597

Reaction equation

methyl 4-(isocyanatocarbonyl)-2-methoxybenzoate

tert-butyl 2-(2,6-dichlorophenyl)hydrazinecarboxylate

→

desired product

Yield 81.1%

tert-butyl 2-(2,6-dichlorophenyl)-2-((3-methoxy-4-(methoxycarbonyl)benzoyl)carbamoyl)hydrazinecarboxylate

Yield 81.1%

Solvents

DCM

Conditions

Workup

1. 1
   OtherThe title compound was prepared

Procedure

The title compound was prepared according to the procedure described in step-1 of Intermediate-9 by using methyl 4-(isocyanatocarbonyl)-2-methoxybenzoate (0.84 g, 3.61 mmol), tert-butyl 2-(2,6-dichlorophenyl)hydrazinecarboxylate (Intermediate-44, 1.0 g, 3.61 mmol) and DCM (20 mL) to afford 1.50 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 1.35 (s, 9H), 3.80 (s, 3H), 3.87 (s, 3H), 7.28-7.42 (m, 6H), 9.57 (s, 1H), 10.85 (s, 1H); MS (m/z): 511.73 (M)+.

Source