Reaction #8732

Reaction equation

sodium carbonate

3-fluorobenzylamine

1,2-dibromoethane

→

desired compound

(2-bromo-ethyl)-(3-fluoro-benzyl)-amine

Solvents

water

Conditions

Workup

1. 1
   OtherRemove the unreacted 1,2-dibromoethane
2. 2
   workup.DISTILLATIONby distillation
3. 3
   ExtractionExtract the left-over residue with ether
4. 4
   Otherevaporate

Procedure

Combine 3-fluorobenzylamine (5.0 g, 0.0400 mol), fused sodium acetate (3.28 g, 0.0400 mol) and 1,2-dibromoethane (7.51 g, 0.0400 mol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,2-dibromoethane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound. The compound can form the hydrochloride salt.

Source