Reaction #85467

ord-b22517412c8d409da5bfd66214415b4d

Reaction equation

CCOc1ccccc1I
ethoxyiodobenzene
O=C1Nc2cc(F)c(Cl)cc2C1=O
5-chloro-6-fluoroisatin
O=C1Nc2ccccc2C1=O
isatin
→
CCOc1ccccc1C1(O)C(=O)Nc2cc(F)c(Cl)cc21
title compound
CCOc1ccccc1C1(O)C(=O)Nc2cc(F)c(Cl)cc21
5-Chloro-3-(2-ethoxyphenyl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one

Reactants

CCOc1ccccc1I
ethoxyiodobenzene
O=C1Nc2cc(F)c(Cl)cc2C1=O
5-chloro-6-fluoroisatin
O=C1Nc2ccccc2C1=O
isatin

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared in analogy to example a.1 using 5-chloro-6-fluoroisatin as isatin II and ethoxyiodobenzene (to form the Grignard reagent).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434713B2uspto-grants-2016_09