Reaction #85466

ord-9d6951232918402db41f989e083e6721

Reaction equation

FC(F)COc1ccccc1I
2,2-difluoroethoxyiodobenzene
O=C1Nc2cc(F)c(Cl)cc2C1=O
5-chloro-6-fluoroisatin
O=C1Nc2ccccc2C1=O
isatin
→
O=C1Nc2cc(F)c(Cl)cc2C1(O)c1ccccc1OCC(F)F
title compound
O=C1Nc2cc(F)c(Cl)cc2C1(O)c1ccccc1OCC(F)F
5-Chloro-3-[2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one

Reactants

FC(F)COc1ccccc1I
2,2-difluoroethoxyiodobenzene
O=C1Nc2cc(F)c(Cl)cc2C1=O
5-chloro-6-fluoroisatin
O=C1Nc2ccccc2C1=O
isatin

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared in analogy to example a.1 using 5-chloro-6-fluoroisatin as isatin II and 2,2-difluoroethoxyiodobenzene (to form the Grignard reagent).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434713B2uspto-grants-2016_09