Reaction #854

Reaction equation

1,5-Naphthalenediamine

benzylisothiocyanate

→

colorless crystal

Yield 30.7%

1,5-di(benzylthiocarbamoylamino)naphthalene

Yield 30.7%

Solvents

ethyl acetate

Conditions

Workup

1. 1
   TemperatureAfter cooling
2. 2
   Filtrationthe reaction mixture was filtered
3. 3
   Washwashed with ethylacetate/n-hexane

Procedure

1,5-Naphthalenediamine (0.791 g, 5 mM) was dissolved in 20 ml of ethyl acetate, and 2 equivalents of benzylisothiocyanate (1.492 g, 10 mM) were added. The mixture was stirred at 80° C. for 30 minutes. After cooling, the reaction mixture was filtered, and washed with ethylacetate/n-hexane to obtain 0.70 g (30.7% yield) of a colorless crystal of compound A-29.

Source