Reaction #8536

Reaction equation

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

Yield 96.0%

2-(2,3,4-Trifluoroanilino)propionic acid

Yield 96.0%

Solvents

methanol

Conditions

Workup

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Concentrationthe obtained filtrate was concentrated under reduced pressure

Procedure

2,3,4-Trifluoronitrobenzene (1.01 g) and pyruvic acid (0.75 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 4.9 MPa (converted from 50 kgf/cm2) for 5 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.20 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Source