Reaction #8534

Reaction equation

2,3,4-Trifluoronitrobenzene

pyruvic acid

hydrogen

→

title compound

Yield 98.1%

2-(2,3,4-Trifluoroanilino)propionic acid

Yield 98.1%

Solvents

isopropanol

Conditions

Workup

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Concentrationthe obtained filtrate was concentrated under reduced pressure

Procedure

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in isopropanol (IPA; 40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.11 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Source