Reaction #85013

Reaction equation

2,5-dimethoxypyridin-4-ylboronic acid

2-bromo-4-chlorobenzonitrile

→

4-Chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile

Conditions

Procedure

7.87 g (purity 95%, 40.86 mmol) of 2,5-dimethoxypyridin-4-ylboronic acid and 8.85 g (40.86 mmol) of 2-bromo-4-chlorobenzonitrile in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 6.23 g (purity 92%, 51% of theory)

Source