Reaction #84975

ord-5991690ccc954c0fab11192a84916375

Reaction equation

COc1cc(-c2cc(Cl)ccc2C#N)c(OC)cn1
4-chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile
Cl.c1cc[nH+]cc1
pyridinium hydrochloride
→
N#Cc1ccc(Cl)cc1-c1cc(=O)[nH]cc1Cl
4-Chloro-2-(5-chloro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile

Reactants

COc1cc(-c2cc(Cl)ccc2C#N)c(OC)cn1
4-chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile
Cl.c1cc[nH+]cc1
pyridinium hydrochloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

6.34 g (purity 93%, 21.12 mmol) of 4-chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile and pyridinium hydrochloride were reacted according to General Method 3A. Yield: 4.23 g (76% of theory)

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09434690B2uspto-grants-2016_09