Reaction #848

Reaction equation

p-hydroxybenzoic acid

decanoic acid chloride

pyridine

→

p-decanoyloxybenzoic acid

Solvents

water

Conditions

Workup

1. 1
   Extractionan organic layer was extracted with dichloromethane
2. 2
   WashThe organic layer was washed with 1N hydrochloric acid
3. 3
   Dryingdried over anhydrous sodium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   Washresidue was washed with n-hexane
6. 6
   Otherdried
7. 7
   Otherto give a crude end product

Procedure

10 Grams of p-hydroxybenzoic acid and 15 g of decanoic acid chloride were stirred at room temperature, and 7.2 g of pyridine was dropwise added. After the mixture was stirred for 1 day, a reaction product was poured into water, and an organic layer was extracted with dichloromethane. The organic layer was washed with 1N hydrochloric acid and dried over anhydrous sodium sulfate, the solvent was distilled off, and then residue was washed with n-hexane and then dried to give a crude end product.

Source