Reaction #8443

ord-d113d1d13d1a417184600b4984e0e239

Reaction equation

CCOC(=O)CC(=O)c1ccccc1
ethylbenzoylacetate
CCOc1ccc2cc(C=O)c(Cl)nc2c1
( a )
CCOc1ccc2cc(C=O)c(Cl)nc2c1
2-Chloro-3-formyl-7-ethoxy-quinoline
→
COc1ccc2cc(C(=O)O)c(-c3ccccc3)nc2c1
7-Methoxy-2-phenyl-quinoline-3-carboxylic acid

Reactants

CCOC(=O)CC(=O)c1ccccc1
ethylbenzoylacetate
CCOc1ccc2cc(C=O)c(Cl)nc2c1
( a )
CCOc1ccc2cc(C=O)c(Cl)nc2c1
2-Chloro-3-formyl-7-ethoxy-quinoline

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Othergave the

Procedure

Following the procedure of Example 36 (a)-(b) substituting ethylbenzoylacetate in step 36 (a) gave the above named compound. LCMS m/e [M+H]+=280.2

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087758B2uspto-grants-2006_08