Reaction #84076

ord-a385949fc06b408db7bfa60e8745d101

Reaction equation

COc1ccc2nc(Cl)c(Cl)cc2c1
2,3-dichloro-6-methoxyquinoline
COc1ccc2nc(Cl)c(Cl)cc2c1
Intermediate 4
COc1ccc2nc(Cl)c(Cl)cc2c1
2,3-dichloro-6-methoxyquinoline
O=C(O)c1ccc(B(O)O)cc1
4-boronobenzoic acid
→
COc1ccc2nc(-c3ccc(C(=O)O)cc3)c(Cl)cc2c1
4-(3-chloro-6-methoxyquinolin-2-yl)benzoic acid

Reactants

COc1ccc2nc(Cl)c(Cl)cc2c1
2,3-dichloro-6-methoxyquinoline
COc1ccc2nc(Cl)c(Cl)cc2c1
Intermediate 4
COc1ccc2nc(Cl)c(Cl)cc2c1
2,3-dichloro-6-methoxyquinoline
O=C(O)c1ccc(B(O)O)cc1
4-boronobenzoic acid

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Followed Scheme 3 where the starting materials were 2,3-dichloro-6-methoxyquinoline (Intermediate 4) and 4-boronobenzoic acid.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09433618B2uspto-grants-2016_09