Reaction #84074

ord-1fd770a70c3c4c6482b925ff4de26417

Reaction equation

Oc1ccc2nc(Cl)ccc2c1
2-chloroquinolin-6-ol
COC(=O)C1CC=C(B2OC(C)(C)C(C)(C)O2)CC1
methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate
→
COC(=O)C1CC=C(c2ccc3cc(O)ccc3n2)CC1
methyl 4-(6-hydroxyquinolin-2-yl)cyclohex-3-enecarboxylate

Reactants

Oc1ccc2nc(Cl)ccc2c1
2-chloroquinolin-6-ol
COC(=O)C1CC=C(B2OC(C)(C)C(C)(C)O2)CC1
methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol and methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09433618B2uspto-grants-2016_09