Reaction #84068

Reaction equation

2-chloroquinolin-6-ol

H2O

4-cyanophenylboronic acid

1,4-Dioxane

Intermediate 2

2-chloroquinolin-6-ol

→

4-(6-hydroxyquinolin-2-yl)benzonitrile

Solvents

—

hexanes

EtOAc

Ethyl acetate

Conditions

Workup

1. 1
   OtherReaction

Procedure

Followed Scheme 3 starting from 2-chloroquinolin-6-ol (Intermediate 2) and 4-cyanophenylboronic acid, and using 1,4-Dioxane:H2O solution. Reaction was run at 100° C. in a microwave reactor for 1 hour. Ethyl acetate workup was followed by column chromatography (5% to 50% EtOAc in hexanes gradient).

Source