Reaction #84024

Reaction equation

t-Butanol

oxalyl chloride

→

t-butyl 2-chloro-2-oxoacetate

Yield 40.8%

Solvents

DCM

Conditions

Workup

1. 1
   ConcentrationThe reaction mixture was then concentrated in vacuo

Procedure

t-Butanol (574 μL, 6.0 mmol) was added to a solution of oxalyl chloride (772 μL, 9.0 mmol) in DCM (3 mL) at 0° C., and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was then concentrated in vacuo to yield t-butyl 2-chloro-2-oxoacetate (403 mg) as a clear colorless liquid. The liquid was dissolved in DCM (2.5 mL) to prepare a 1.0 M solution in DCM.

Source