Reaction #821340

ord-9b1285cf1063403ba209da9cfbe270a0

Reaction equation

Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F
dihydrochloride
Cc1cc([N+](=O)[O-])ccc1NCCN(CCO)CCO
2-[[2-(4-nitro-2-methylphenylamino)ethyl]-(2-hydroxyethyl)amino]ethanol
Cc1cc(N)ccc1NCCN(CCO)CCO.Cl.Cl
amine
Cc1cc(N)ccc1NCCN(CCO)CCO.Cl.Cl
2-[[2-(4-amino-2-methylphenylamino)ethyl]-(2-hydroxyethyl)amino]ethanol Dihydrochloride

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The 2-[[2-(4-nitro-2-methylphenylamino)ethyl]-(2-hydroxyethyl)amino]ethanol (17) obtained above was reduced with a boiling zinc/ammonium chloride/water/ethanol mixture. The corresponding amine was isolated in dihydrochloride form.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07591860B2uspto-grants-2009_09