Reaction #816393

Reaction equation

phytandiol

para-toluene sulfonyl phytandiol

sodium azide

azide

→

azido phytandiol

Yield 81.6%

Solvents

dimethyl formamide

Conditions

Workup

1. 1
   Temperatureby reflux for 5 hr in order
2. 2
   ExtractionThe reaction mixture was extracted with 50 ml of methylene chloride solution
3. 3
   Washwashed with saline
4. 4
   DryingFollowing drying over anhydrous magnesium sulfate, filtration and concentration

Procedure

The yielded phytandiol derivative (0.48 g) was dissolved in 25 ml of dimethyl formamide and 0.06 g (1.00 mmol) of sodium azide (Sigma-Aldrich) was added, followed by reflux for 5 hr in order to substitute azide for para-toluene sulfonyl group. The reaction mixture was extracted with 50 ml of methylene chloride solution and washed with saline. Following drying over anhydrous magnesium sulfate, filtration and concentration, 0.29 g of azido phytandiol derivative was yielded.

Source