Reaction #816381
ord-bad6b7ac787d4392981673cf6b4e96a8
Reaction equation
3,6-di(azido)-1,2,4,5-tetrazine
3,6-bis(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine
NH2NH2.H2O
→
3,6-di(hydrazino)-1,2,4,5-tetrazine
Reactants
Reagents
None
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Procedure
The invention also includes a method for preparing 3,6-di(azido)-1,2,4,5-tetrazine. The method involves reacting 3,6-bis(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine with NH2NH2.H2O to form 3,6-di(hydrazino)-1,2,4,5-tetrazine (DHT), then reacting the 3,6-di(hydrazino)-1,2,4,5-tetrazine with an aqueous hydrochloric acid solution of NaNO2, thereby forming a crude reaction product comprising 3,6-di(azido)-1,2,4,5-tetrazine and solid impurities, and extracting the 3,6-di(azido)-1,2,4,5-tetrazine away from the impurities in the crude reaction product.