Reaction #81439

ord-b91e2a6074184812bdc8055dcbb81d30

Reaction equation

CN(Cc1ccccc1)c1ncnc2c(N3CCOCC3)nc(N3CCC4(CC3)OCCO4)nc12

2-(8-aza-1,4-dioxaspiro[4,5]decan-8-yl)-8-(N-benzyl-N-methyl-amino) -4-morpholino-pyrimido [5,4-d]pyrimidine

CN(Cc1ccccc1)c1ncnc2c(N3CCOCC3)nc(Cl)nc12

2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine

→

8-aza-1,4-dioxaspiro-[4,5]decane

Yield 58.0%

Reactants

2-(8-aza-1,4-dioxaspiro[4,5]decan-8-yl)-8-(N-benzyl-N-methyl-amino) -4-morpholino-pyrimido [5,4-d]pyrimidine

2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine

Reagents

None

Conditions

Detailed conditions

See reaction.notes.procedure_details.

Procedure

2-(8-aza-1,4-dioxaspiro[4,5]decan-8-yl)-8-(N-benzyl-N-methyl-amino) -4-morpholino-pyrimido [5,4-d]pyrimidine From 2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine and 8-aza-1,4-dioxaspiro-[4,5]decane Yield: 58% of theory, Melting point: 143° C. C25H31N7O3 (477.58)

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05618814uspto-grants-1997_04