Reaction #81435

ord-6e6fbec6a1044fc9915fdf4a2e10cf88

Reaction equation

CN(Cc1ccccc1)c1ncnc2c(N3CCOCC3)nc(N3CCC(N4CCCCC4)CC3)nc12
8-(N-benzyl-N-methyl-amino)-2-[4-(piperidino)-piperidin-1-yl]-4-morpholino-pyrimido [5,4-d]pyrimidine
CN(Cc1ccccc1)c1ncnc2c(N3CCOCC3)nc(Cl)nc12
2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine
→
C1CCN(C2CCNCC2)CC1
4-piperidino-piperidine
Yield 54.0%

Reactants

CN(Cc1ccccc1)c1ncnc2c(N3CCOCC3)nc(N3CCC(N4CCCCC4)CC3)nc12
8-(N-benzyl-N-methyl-amino)-2-[4-(piperidino)-piperidin-1-yl]-4-morpholino-pyrimido [5,4-d]pyrimidine
CN(Cc1ccccc1)c1ncnc2c(N3CCOCC3)nc(Cl)nc12
2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

8-(N-benzyl-N-methyl-amino)-2-[4-(piperidino)-piperidin-1-yl]-4-morpholino-pyrimido [5,4-d]pyrimidine From 2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine and 4-piperidino-piperidine Yield: 54% of theory, Melting point: 106° C. C28H38N8O (502.67)

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05618814uspto-grants-1997_04