Reaction #80359

Reaction equation

N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide

2-mercapto-5-methyl -1,3,4-thiadiazole

→

title compound

Yield 78.0%

N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(5-methyl-1,3,4-thiadiazol-2-ylthio)butyramide

Yield 78.0%

Conditions

Procedure

Following a procedure similar to that described in Example 34, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 2-mercapto-5-methyl -1,3,4-thiadiazole as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a white powder, melting at 65°-68° C., in a 78% yield.

Source