Reaction #80356

Reaction equation

N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide

2-mercapto-1-methylimidazole

→

title compound

Yield 49.0%

N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(1-methylimidazol-2-ylthio)butyramide

Yield 49.0%

Conditions

Procedure

Following a procedure similar to that described in Example 34, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 2-mercapto-1-methylimidazole as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 49% yield.

Source