Reaction #80327

Reaction equation

N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide

2-mercaptoethanol

→

title compound

Yield 66.0%

N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(2-hydroxyethylthio)butyramide

Yield 66.0%

Conditions

Workup

1. 1
   Otherthe reaction at 80° C. for 5 hours

Procedure

Following a procedure similar to that described in Example 1, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 2-mercaptoethanol as starting materials, in relative proportions similar to those used in that Example, and carrying out the reaction at 80° C. for 5 hours, the title compound was obtained in a 66% yield.

Source