Reaction #79494

Reaction equation

hydrochloric acid

water

4-imino-5-methyl-5-phenyl-3-phenylaminothiazolidine-2-thione

→

5-methyl-5-phenyl-3-phenylamino-2-thioxothiazolidin-4-one

Solvents

methanol

Conditions

Workup

1. 1
   OtherThe solvent was then evaporated under reduced pressure
2. 2
   OtherThe residue was purified by column chromatography (ethyl acetate-n-hexane, ⅓)

Procedure

37% hydrochloric acid (5 ml) and water (1 ml) was added at room temperature with stirring to a solution of 4-imino-5-methyl-5-phenyl-3-phenylaminothiazolidine-2-thione (9.38 g) in methanol (50 ml). The solution was stirred for 24 hrs at room temperature. The solvent was then evaporated under reduced pressure. The residue was purified by column chromatography (ethyl acetate-n-hexane, ⅓) to yield an oily 5-methyl-5-phenyl-3-phenylamino-2-thioxothiazolidin-4-one (7.02 g).

Source