Reaction #792208

Reaction equation

4-(4-chlorophenyl)-1H-imidazole

2-bromothiophene

→

4-(4-chlorophenyl)-1-(thiophen-2-yl)-1H-imidazole

Yield 7.0%

Conditions

Procedure

The procedure described above in Example 29 for Formula IIc-iii was followed, starting from 4-(4-chlorophenyl)-1H-imidazole (125 mg, 0.595 mmol) and 2-bromothiophene, to prepare the desired 4-(4-chlorophenyl)-1-(thiophen-2-yl)-1H-imidazole (11 mg, 0.042 mmol, yield 7.0%) as a reddish sticky solid. The HPLC purity of the final product was 95.62%. LC-MS [M+H] 261 (C13H9ClN2S+1 expected 261.02). The 1H-NMR spectra was in accordance with the chemical structure.

Source