Reaction #792146

Reaction equation

(E)-1-(4-hydroxybenzo[d][1,3]dioxol-5-yl)-3-(pyridin-2-yl)prop-2-en-1-one

→

title compound

Yield 59.6%

1-(4-hydroxybenzo[d][1,3]dioxol-5-yl)-3-(pyridin-2-yl)propan-1-one

Yield 59.6%

Solvents

methanol

Conditions

Workup

1. 1
   Otherto give a yellow solution
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Otherevaporated
4. 4
   Washthe solid residue was washed with diethylether
5. 5
   Otherdried

Procedure

(E)-1-(4-hydroxybenzo[d][1,3]dioxol-5-yl)-3-(pyridin-2-yl)prop-2-en-1-one (0.5 g, 1.857 mmol) was added to methanol (50 ml) to give a yellow solution. Palladium on carbon (0.05 g) was added. Product was hydrogenated while stirring till conversion was completed (checked by TLC). The reaction mixture was filtered, evaporated and the solid residue was washed with diethylether, and dried to yield 0.3 g (57%) of the title compound.

Source