Reaction #792145

Reaction equation

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

→

final compound

Yield 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

Yield 84.7%

Solvents

EtOAc

Conditions

Workup

1. 1
   Otherwas conducted at atmospheric pressure room temperature until the starting material
2. 2
   FiltrationThe catalyst was filtered
3. 3
   Otherthe crude was purified by chromatography on silica gel (25% EtOAc/hexane)

Procedure

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

Source