Reaction #78790

ord-8d0e4c3287f74fe482d5d3890498fa10

Reaction equation

Cc1ccc(O)cc1
p-Cresol
OCCCl
2-chloroethanol
[Na+].[OH-]
sodium hydroxide
Cc1ccc(OCCO)cc1
4-(2-hydroxyethoxy)toluene

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

p-Cresol may be reacted with excess 2-chloroethanol in the presence of sodium hydroxide to give 4-(2-hydroxyethoxy)toluene which may be purified by conventional techniques.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06712893B1uspto-grants-2004_03