Reaction #78455

Reaction equation

[4-(3-ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-di-pyridin-3-yl-methanol

HCl

→

title compound

Yield 44.3%

4-(3-Ethoxy-phenyl)-6-(hydroxy-di-pyridin-3-yl-methyl)-1H-quinolin-2-one

Yield 44.3%

Solvents

THF

Conditions

Procedure

Following the same procedure as described in example 1F, [4-(3-ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-di-pyridin-3-yl-methanol (212 mg, 0.457 mmol) was treated with HCl in aqueous THF to yield the title compound (91 mg, 44.3% yield).

Source