Reaction #76937

ord-85526ed23bca4cadb51a3bf7cc6103eb

Reaction equation

COc1ccc(CC2NCCc3c(OC)ccc(OC)c32)cc1OC
1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NCc1ccccc1F
2-fluorobenzylamine
→
COc1ccc(CC2c3c(OC)ccc(OC)c3CCN2CC(=O)NCc2ccccc2F)cc1OC
2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-acetamide

Reactants

COc1ccc(CC2NCCc3c(OC)ccc(OC)c32)cc1OC
1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NCc1ccccc1F
2-fluorobenzylamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-fluorobenzylamine

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03