Reaction #7693

Reaction equation

DCC

triethylamine

cyanoacetic acid

(R)-N-benzoyl-3-methylpiperazine

→

(R)-N-benzoyl-3-methyl-N′-(2-cyano-acetyl)piperazine

Yield 94.1%

Solvents

THF

Conditions

Workup

1. 1
   OtherAfter reaction
2. 2
   Othersolvents were removed under vacuum
3. 3
   Otherto give a residue which
4. 4
   Otherwas purified by silica gel column chromatography

Procedure

DCC (2.43 g) and triethylamine (5 ml) were added into a solution of cyanoacetic acid (1.00 g) and (R)-N-benzoyl-3-methylpiperazine (2.84 g) in THF (50 ml). After reaction stirred at room temperature for 12 hours, solvents were removed under vacuum to give a residue which was purified by silica gel column chromatography to afford 3 g of (R)-N-benzoyl-3-methyl-N′-(2-cyano-acetyl)piperazine. MS m/z: (M+H)+ calcd for C15H18N3O2 272.14, found 272.17. HPLC retention time: 0.93 minutes (column H).

Source