Reaction #76927

ord-663c7b2f53ad40e4bbe2224b4c080a29

Reaction equation

COc1ccc(C[C@@H]2NCCc3cc(OC)c(OC)cc32)cc1OC
(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
CNCc1ccccc1
N-benzyl-N-methylamine
→
COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CCN2CC(=O)N(C)Cc2ccccc2)cc1OC
2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide

Reactants

COc1ccc(C[C@@H]2NCCc3cc(OC)c(OC)cc32)cc1OC
(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
CNCc1ccccc1
N-benzyl-N-methylamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methylamine

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03