Reaction #76925

ord-adf06fb7d19846748a18a414f9207324

Reaction equation

COc1ccc(C[C@@H]2NCCc3cc(OC)c(OC)cc32)cc1OC
(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
COc1ccccc1CN
2-methoxy-benzylamine
→
COc1ccccc1CNC(=O)CN1CCc2cc(OC)c(OC)cc2[C@@H]1Cc1ccc(OC)c(OC)c1
2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide

Reactants

COc1ccc(C[C@@H]2NCCc3cc(OC)c(OC)cc32)cc1OC
(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
COc1ccccc1CN
2-methoxy-benzylamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzylamine

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03