Reaction #76896

ord-763d34956f834460bf63dee93e40206e

Reaction equation

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
COc1ccc(CN)cc1
4-methoxybenzylamine
→
COc1ccc(CNC(=O)CN2CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1
2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methoxy-benzyl)-acetamide

Reactants

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
COc1ccc(CN)cc1
4-methoxybenzylamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methoxybenzylamine

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03