Reaction #76895

ord-1f916e7844b94f0da387f4475b4f2475

Reaction equation

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
COc1ccccc1CN
2-methoxybenzylamine
→
COc1ccccc1CNC(=O)CN1CCc2cc(OC)c(OC)cc2C1Cc1ccc(OC)c(OC)c1
2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide

Reactants

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
COc1ccccc1CN
2-methoxybenzylamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxybenzylamine

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03