Reaction #7657

ord-e8614edd65754b1d8eb7b12fffa62985

Reaction equation

CCC(N)c1nnc(C2CCCC2)[nH]c1=O
6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one
CC(C)(C)C(=O)Cl
2,2-dimethylpropanoyl chloride
→
CCC(NC(=O)C(C)(C)C)c1nnc(C2CCCC2)[nH]c1=O
N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-2,2-dimethylpropanamide

Reactants

CCC(N)c1nnc(C2CCCC2)[nH]c1=O
6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one
CC(C)(C)C(=O)Cl
2,2-dimethylpropanoyl chloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe crude product is used in the next step without further purification

Procedure

In analogy to the procedure for Example 36A, 150 mg (0.67 mmol) 6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one, 90 mg (0.74 mmol) 2,2-dimethylpropanoyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087605B2uspto-grants-2006_08