Reaction #7650

Reaction equation

6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one

bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride

→

N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]bicyclo[2.2.1]hept-5-ene-2-carboxamide

Conditions

Workup

1. 1
   OtherThe crude product is used in the next step without further purification

Procedure

In analogy to the procedure for Example 36A, 150 mg (0.67 mmol) 6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one, 120 mg (0.74 mmol) bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Source