Reaction #7631

ord-4825907718a34102b76de664069c39ba

Reaction equation

CCC(N)C(=O)O
2-aminobutanoic acid
CC(=O)OC(C)=O
acetic anhydride
→
CCC(NC(C)=O)C(=O)O
2-(Acetylamino)butanoic acid

Reactants

CCC(N)C(=O)O
2-aminobutanoic acid
CC(=O)OC(C)=O
acetic anhydride

Reagents

None

Solvents

CC(=O)O
acetic acid

Conditions

Temperature
100°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherthe solution evaporated to dryness in vacuo
  2. 2
    Filtrationfiltered
  3. 3
    Washwashed with diethyl ether

Procedure

163 g (1.58 mol) 2-aminobutanoic acid are dissolved in acetic acid, and 242 g (2.37 mol) acetic anhydride are added dropwise. The mixture is stirred for 2 h at 100° C. until completion of reaction, then the solution evaporated to dryness in vacuo. The solid residue is suspended in ethyl acetate, filtered and washed with diethyl ether.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087605B2uspto-grants-2006_08