Reaction #75710

Reaction equation

8-Fluoro-2-methoxyquinoline-4-carboxylic acid methyl ester

sodium hydroxide

→

8-Fluoro-2-methoxyquinoline-4-carboxylic Acid

Solvents

methanol

Conditions

Workup

1. 1
   OtherSolvent was removed at reduced pressure
2. 2
   workup.DISSOLUTIONdissolved in water
3. 3
   OtherThe precipitated title compound (0.155 g)
4. 4
   Filtrationwas collected by filtration
5. 5
   Otherdried

Procedure

8-Fluoro-2-methoxyquinoline-4-carboxylic acid methyl ester (0.1 82 g) in methanol (10 ml) containing 2N sodium hydroxide (0.41 ml) was stirred at room temperature for 16 h. Solvent was removed at reduced pressure, dissolved in water, and adjusted to pH2 with 2N hydrochloric acid. The precipitated title compound (0.155 g) was collected by filtration and dried. m/z (API−): 222 (MH+). 1H NMR δ: 4.02 (3H, s), 7.44-7.62 (3H, m), 8.31 (1H, d).

Source