Reaction #75656

Reaction equation

3,5-dichloroaniline

ethylglyoxalate

3,5-dimethylstyrene

trifluoroacetic acid

→

Compound 24

5,7-dichloro-4-(3,5-dimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid Ethyl Ester

Solvents

acetonitrile

Conditions

Procedure

Compound 24 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 3,5-dimethylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

Source