Reaction #7552

ord-969acd0d0f2e422ba1015f8da344886c

Reaction equation

O=C([O-])[O-]
carbonate
O=C(O)C(=O)O
oxalic acid
→
O=C(O)C(=O)O.O=C(O)O
carbonate oxalate

Reactants

O=C([O-])[O-]
carbonate
O=C(O)C(=O)O
oxalic acid

Reagents

None

Solvents

CCOC(C)=O
ethyl acetate
CCOC(C)=O
ethyl acetate

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe crystals precipitated
  2. 2
    Filtrationwere collected by filtration

Procedure

In 7 mL of ethyl acetate was dissolved 0.31 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinyl=methyl=carbonate, and to the solution was added a solution of 0.10 g of oxalic acid in 1 mL of ethyl acetate, after which the resulting mixture was stirred at room temperature. The crystals precipitated were collected by filtration to obtain 0.34 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinyl=methyl=carbonate oxalate.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087594B2uspto-grants-2006_08