Reaction #7547

Reaction equation

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol

maleic acid

→

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate

Yield 88.4%

Solvents

acetone

Conditions

Workup

1. 1
   workup.ADDITIONby adding
2. 2
   workup.DISSOLUTIONdissolution
3. 3
   TemperatureThe reaction mixture was slowly cooled
4. 4
   OtherThe crystals precipitated
5. 5
   Filtrationwere collected by filtration

Procedure

In 56 mL of acetone was dissolved 8.00 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol, followed by adding thereto 3.19 g of maleic acid, and the resulting mixture was heated at 60° C. to effect dissolution. The reaction mixture was slowly cooled and then stirred at 5° C. for 30 minutes. The crystals precipitated were collected by filtration to obtain 9.89 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate as colorless crystals.

Source