Reaction #75457

Reaction equation

3,4-dichlorobenzoyl chloride

2-amino-4-chloro-5-nitrophenol

→

2-(3,4-dichlorobenzamido)-4-chloro-5-nitrophenol

Yield 77.0%

Solvents

ethyl acetate

Conditions

Workup

1. 1
   Temperaturethe mixture refluxed for 2 h
2. 2
   TemperatureAfter cooling the precipitate
3. 3
   Filtrationwas filtered
4. 4
   Filtrationfiltered again

Procedure

3,4-dichlorobenzoyl chloride (2) (38.0 g, 0.18 mol) was added to a stirred slurry of 2-amino-4-chloro-5-nitrophenol (1) (34.0 g, 0.18 mol) in ethyl acetate (250 ml) and the mixture refluxed for 2 h. After cooling the precipitate was filtered and then slurried in hot ethyl acetate (200 ml) and filtered again to give 50 g (77%) 2-(3,4-dichlorobenzamido)-4-chloro-5-nitrophenol (3).

Source