Reaction #75396

ord-ab187f9ebedb4aebbe5d70924c7a076a

Reaction equation

CC1(C)N=CC2=C3N=C(C4CCCCC4)N=C3C(=O)CC2C1=O
7,7-dimethyl-2-cyclohexyl-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione
ClCCCBr
1-bromo-3-chloro-propane
→
CC1(C)N=CC2=C3N=C(C4CCCCC4)N=C3C(=O)C(CCCCl)C2C1=O
7,7-Dimethyl-2-cyclohexyl-5-(3-chloro-propyl)-5H,7H-imidazo-[4,5-h]isoquinoline-4,6-dione

Reactants

CC1(C)N=CC2=C3N=C(C4CCCCC4)N=C3C(=O)CC2C1=O
7,7-dimethyl-2-cyclohexyl-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione
ClCCCBr
1-bromo-3-chloro-propane
—
crude product

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared analogous to Example 26a from 3.1 gm of 7,7-dimethyl-2-cyclohexyl-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione and 1.9 gm of 1-bromo-3-chloro-propane. The crude product was directly further processed.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04176184uspto-grants-1979_11