Reaction #75249

Reaction equation

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid

hydrogen

→

title compound

4-[4-Acetyl-7-(1-hydroxycyclohexyl)heptyl]benzoic Acid

Solvents

ethyl acetate

Conditions

Workup

1. 1
   Otherat 1 atmosphere pressure and room temperature
2. 2
   FiltrationThe catalyst is filtered off
3. 3
   Otherthe solvent is evaporated
4. 4
   Otherthe residue (5 g.) is chromatographed on 75 g

Procedure

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid (5.1 g., 0.014 mole) in ethyl acetate (55 ml.) is hydrogenated over 2.0 g. of a 5% Pt on charcoal catalyst at 1 atmosphere pressure and room temperature. The theoretical amount of hydrogen (0.028 mole) is absorbed in 25 minutes. The catalyst is filtered off, the solvent is evaporated and the residue (5 g.) is chromatographed on 75 g. of silica gel with 2% methanol in chloroform as eluant. The title compound is obtained as a colorless viscous oil.

Source