Reaction #75034

Reaction equation

2-butylamino-4-methyloxazole

hexyl isocyanate

→

product

1-Butyl-3-hexyl-1-(4-methyl-2-oxazolyl)urea

Solvents

benzene

Conditions

Workup

1. 1
   Temperatureunder reflux for 3 hours
2. 2
   OtherThe solution was evaporated
3. 3
   workup.DISSOLUTIONthe residual oil dissolved in ether
4. 4
   Washwashed with dilute HCl
5. 5
   Otherdried
6. 6
   Otherre-evaporated
7. 7
   workup.DISSOLUTIONThe residue was dissolved in petroleum spirit (40°-60° C.) carbon
8. 8
   workup.ADDITIONtreated
9. 9
   Otherre-evaporated under vacuum

Procedure

A solution of 2-butylamino-4-methyloxazole (10.0 g, 0.065 mol) and hexyl isocyanate (8.25 g, 0.065 mol) in dry benzene was heated under reflux for 3 hours. The solution was evaporated and the residual oil dissolved in ether, washed with dilute HCl, dried and re-evaporated. The residue was dissolved in petroleum spirit (40°-60° C.) carbon treated and re-evaporated under vacuum to give the pure product as a pale oil.

Source