Reaction #747256

ord-0231db966997450ca636306a19a811fc

Reaction equation

O=C(O)C(=O)c1ccccc1
benzoyl formic acid
COC(=O)C(=O)c1ccccc1
methyl benzoyl formate
Cc1ccccc1C(O)(C(=O)O)c1ccccc1
hydroxy-phenyl-o-tolyl-acetic acid
Cc1ccccc1C(O)(C(=O)O)c1ccccc1
Intermediate M
Cc1ccccc1C(O)(C(=O)O)c1ccccc1
hydroxy-phenyl-o-tolyl-acetic acid
BrCOc1ccccc1
2-bromomethoxy benzene
COc1ccccc1C(O)(C(=O)O)c1ccccc1
Hydroxy-(2-methoxy-phenyl)-phenyl-acetic acid

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

This compound is prepared by an analogous method to hydroxy-phenyl-o-tolyl-acetic acid (Intermediate M) by replacing bromotoluene with 2-bromomethoxy benzene and benzoyl formic acid with methyl benzoyl formate.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08084463B2uspto-grants-2011_12