Reaction #7435

Reaction equation

2-(ethyl(4-formylphenyl)amino)ethyl acetate

cyclohexanone

sodium hydroxide

→

2,6-bis((4-(ethyl(2-hydroxyethyl) amino)phenyl)methylene) cyclohexan-1-on e

Yield 185.2%

Solvents

ethanol

Conditions

Workup

1. 1
   workup.STIRRINGThis mixture was further stirred for 5 hours
2. 2
   TemperatureAfter cooling to room temperature
3. 3
   Filtrationa precipitate was filtrated
4. 4
   Washwashed with a small amount of ethanol and water

Procedure

23.5 g of 2-(ethyl(4-formylphenyl)amino)ethyl acetate, 4.91 g of cyclohexanone and 150 ml of ethanol were mixed and to this was added an aqueous solution (25 ml) of 2.2 g of sodium hydroxide while stirring at 50° C. This mixture was further stirred for 5 hours. After cooling to room temperature, a precipitate was filtrated, and washed with a small amount of ethanol and water to obtain 41.5 g of 2,6-bis((4-(ethyl(2-hydroxyethyl) amino)phenyl)methylene) cyclohexan-1-on e.

Source