Reaction #74348

ord-1e7764203ffd43cdb2825bbc1746b206

Reaction equation

NC(=S)NC1CC2CCC1C2

N-bicyclo[2.2.1]hept-2-ylthiourea

COC(=O)C1(Br)CCCCC1

methyl 1-bromocyclohexanecarboxylate

→

O=C1N=C(NC2CC3CCC2C3)SC12CCCCC2

2-(Bicyclo[2.2.1]hept-2-ylamino)-1-thia-3-azaspiro[4.5]dec-2-en-4-one

Reactants

N-bicyclo[2.2.1]hept-2-ylthiourea

methyl 1-bromocyclohexanecarboxylate

Reagents

None

Conditions

Detailed conditions

See reaction.notes.procedure_details.

Workup

1
OtherSynthesis

Procedure

Synthesis was performed from N-bicyclo[2.2.1]hept-2-ylthiourea and methyl 1-bromocyclohexanecarboxylate according to Method D.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541592B2uspto-grants-2013_09