Reaction #74341

ord-b8ea552c39e9439284fbaacab23822ab

Reaction equation

N[C@@H](Cc1ccc(O)cc1)C(=O)O
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
NC(=S)NC1CCCCCCC1
N-cyclooctylthiourea
→
O=C1N=C(NC2CCCCCCC2)SC1Cc1ccc(O)cc1
2-(cyclooctylamino)-5-(4-hydroxybenzyl)-1,3-thiazol-4(5H)-one

Reactants

N[C@@H](Cc1ccc(O)cc1)C(=O)O
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
NC(=S)NC1CCCCCCC1
N-cyclooctylthiourea

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherSynthesis

Procedure

Synthesis was performed from (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid and N-cyclooctylthiourea according to Method E and C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541592B2uspto-grants-2013_09